The ZAL Sevilla is located on land belonging to the Port of Sevilla, right in the centre of the city and beside the SE-30 ring-road and intermediate urban ring-roads, which enable it to combine local, regional, national and international distribution.

Access to the ZAL is from the Esclusa road, with a direct link to the SE-30 highway, through the Puerto Oeste exit and the Ronda Mª Auxiliadora-los Remedios.